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There are a numerous of causes for depression, which can be caused by stressful situations, major traumatic events, chemical imbalances in the brain, or other troubles. It may be related to genetic makeup, since people who are major depressive disorder also tend to have family members who are depressed, even if these people are not in contact. No matter what its reason, depression causes significant emotional pain and is a trouble to many people's lives. It affects their friends and family, makes them less productive at work and more likely to call in ill or even lose their jobs, and it can cause many other problems, as well.

Major depressive disorder can be more easily treated at the earlier stages:-

• The attentiveness of a person with major depressive disorder is impaired.
• A clinically major depressive disorder person is unable to feel pleasure. Even the things that used to please him before seem to have no result once he is into depression.
• The sleep of a depressed person is troubled. Once he wakes up in the middle of the night, he finds it hard to fall back to sleep again.
• A depressed person has no hunger for food. Even favorite foods seem to be bland.
• The depressed person still feels tired even after sleeping for long hours.

There is a strong feeling of guilt, despair and helplessness in a depressed person. There is an event that happens in the past that seems to nag the person and caused him not to forgive himself or to experience very hopeless.

At work, the major depressive disorder person seems to decline in output. He no longer delivers the way he used to. There is an amazing change in the character of the person that other people might discover strange. Others tend to cut off themselves, as if building a world of their own.